反应详情

5 g of 3-nitrophenylethanol, 9.4 g of triphenylphosphine and 3.1 g of imidazole are dissolved in 250 ml of THF, mixed in portions with 9.1 g of iodine and stirred for 15 hours at room temperature. The reaction mixture is mixed with ammonium chloride solution and extracted with dichloromethane. The organic phase is washed in succession with sodium thiosulfate solution and water and dried on sodium sulfate. After purification by chromatography on silica gel, 7.51 g of the title compound is obtained.

1. extractionextracted with dichloromethane
2. washThe organic phase is washed in succession with sodium thiosulfate solution and water
3. customdried on sodium sulfate
4. customAfter purification by chromatography on silica gel