反应详情

10 g of 2-bromo-1-(3-nitro-phenyl)-ethanone is dissolved in 200 ml of ethanol, mixed with 1.55 g of sodium borohydride and stirred for 1 hour at room temperature. 2.1 g of potassium hydroxide is added, and it is stirred for another 15 hours at room temperature. 1000 ml of ethyl acetate is added, and it is washed twice with 300 ml of semi-saturated ammonium chloride solution and once with 100 ml of water. The organic phase is dried on sodium sulfate. After purification by chromatography on silica gel, 7.48 g of the title compound is obtained.

1. stirringit is stirred for another 15 hours at room temperature
2. washit is washed twice with 300 ml of semi-saturated ammonium chloride solution and once with 100 ml of water
3. customThe organic phase is dried on sodium sulfate
4. customAfter purification by chromatography on silica gel