2-Iodobenzoic acid → HCID 22058256, compound

HRID 1787723Notes

Reaction equation

HRID 1787723 reaction equation
[CH3:1][CH2:2][O:3][C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([NH2:10])[CH:5]=1.[OH-].[K+].I[C:14]1[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=1[C:16]([OH:18])=[O:17]>[Cu].O>[CH2:2]([O:3][C:4]1[CH:5]=[C:6]([NH:10][C:14]2[CH:22]=[CH:21][CH:20]=[CH:19][C:15]=2[C:16]([OH:18])=[O:17])[CH:7]=[CH:8][CH:9]=1)[CH3:1]

Participants

6

Reactant 3

HCID 69412-Iodobenzoic acidHCID 121203-EthoxyanilineHCID 14797Potassium Hydroxide

Product 1

HCID 22058256HCID 22058256, compound

Reagents, catalysts & solvents 2

HCID 23978CopperCatalystHCID 962WaterSolvent

Procedure

m-Phenetidine (5 ml, 38.7 mmol) is added to a solution of KOH (7.385 g, 131.6 mmol), water (77 ml) and 2-iodobenzoic acid (9.6 g, 38.7 mmol). Powdered copper (77 mg, 1.22 μmol) is added and the mixture is refluxed under stirring over night (16 h).

Workup

  1. temperaturethe mixture is refluxed

Sources & evidence

ORD record
ord-98b2c4adc68c4744a60a514a1cbaff45
Source dataset
uspto-grants-2009_03
Patent number
US07511064B2

Reaction notes

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