反应详情

A mixture of 4-[[(benzoylamino)carbonothioyl](pentyl)amino]-1H-imidazole-5-carboxamide (11.8 g, 0.0263 mol) and 1 M of sodium hydroxide in water (75 mL) was heated to reflux for 3 h. Solid was formed in the reaction mixture. The reaction mixture was adjusted to pH 3-4 with concentrated HCl with cooling in an ice bath. The solid was filtered, washed with water and air-dried to give the product (9.0 g, 65% purity, 94% yield). The product was used for the next step without further purification. LCMS calculated for C10H15N4OS (M+H): 239.1; found: 239.1.

1. temperaturewas heated
2. temperatureto reflux for 3 h
3. customSolid was formed in the reaction mixture
4. temperaturewith cooling in an ice bath
5. filtrationThe solid was filtered
6. washwashed with water
7. customair-dried
8. customto give the product (9.0 g, 65% purity, 94% yield)
9. customThe product was used for the next step without further purification