N-bromobutanimide → HCID 25061976, compound

HRID 1787762Notes

Reaction equation

HRID 1787762 reaction equation
[CH2:1]([N:5]1[C:13]2[N:12]=[CH:11][NH:10][C:9]=2[C:8](=[O:14])[N:7]2[CH:15]=[N:16][N:17]=[C:6]12)[CH2:2][CH2:3][CH3:4].[Br:18]N1C(=O)CCC1=O>C1COCC1>[Br:18][C:11]1[NH:10][C:9]2[C:8](=[O:14])[N:7]3[CH:15]=[N:16][N:17]=[C:6]3[N:5]([CH2:1][CH2:2][CH2:3][CH3:4])[C:13]=2[N:12]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 57600223HCID 57600223, compound

Product 1

HCID 25061976HCID 25061976, compoundYield 6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
70 °C

Procedure

To a mixture of 9-butyl-6,9-dihydro-5H-[1,2,4]triazolo[4,3-a]purin-5-one (65 mg, 0.28 mmol) in THF (2 mL) was added N-bromosuccinimide (49.8 mg, 0.280 mmol). The mixture was heated in a microwave reactor at 70° C. for 10 minutes. The mixture was purified with prep LCMS to give the desired product (4.8 mg, 6%). LCMS calculated for C10H12BrN6O (M+H): 311.0; found: 311.0, 313.0.

Workup

  1. customThe mixture was purified with prep LCMS

Sources & evidence

ORD record
ord-b140080bbe96414aa828afd3e38d600e
Source dataset
uspto-grants-2009_03
Patent number
US07511050B2

Reaction notes

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