反应详情

A mixture of ethyl 4-(4-phenyl-1H-pyrazol-1-yl)butanoate (273 mg, 1.06 mmole) in methanol (5 ml) and 1N NaOH (5 mL) was stirred at room temperature for 2 hours. The reaction mixture was adjusted to be acidic (pH=3-4) with 6 N HCl with an ice bath and then extracted with EtOAc (3×). The combined organic phases were washed with water and brine, dried over Na2SO4, filtered and concentrated to give the desired product (190 mg, 78%). LCMS calculated for C13H15N2O2 (M+H): 231.1; found: 231.1.

1. extractionextracted with EtOAc (3×)
2. washThe combined organic phases were washed with water and brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated