HCID 68877757, compound → HCID 11198003, compound

HRID 1787839Notes

Reaction equation

HRID 1787839 reaction equation
C([O:4][CH:5]([C:18]1[CH:23]=[CH:22][C:21]([O:24]CC2C=CC=CC=2)=[C:20]([CH2:32][OH:33])[CH:19]=1)[CH2:6][NH:7][C:8]([CH3:17])([CH3:16])[CH2:9][CH2:10][N:11]1[CH:15]=[N:14][N:13]=[CH:12]1)(=O)C.[H][H]>[Pd].CO>[CH3:17][C:8]([NH:7][CH2:6][CH:5]([C:18]1[CH:23]=[CH:22][C:21]([OH:24])=[C:20]([CH2:32][OH:33])[CH:19]=1)[OH:4])([CH3:16])[CH2:9][CH2:10][N:11]1[CH:15]=[N:14][N:13]=[CH:12]1

Participants

5

Reactant 2

HCID 68877757HCID 68877757, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 11198003HCID 11198003, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

5 g of 1-(4-benzyloxy-3-hydroxymethyl-phenyl)-2-(1,1-dimethyl-3-[1,2,4]triazol-4-yl-propylamino)-ethanol acetate are hydrogenated with 0.5 g of palladium on charcoal (5%) in 100 mL methanol. After the theoretically calculated amount of hydrogen has been taken up the catalyst is filtered off and the filtrate is evaporated down. The residue is dissolved in 10 mL ethanol and seeded. Then the product that crystallises out is suction filtered and washed. Yield: 3.2 g (74%, acetate); m.p.=125-127° C.

Workup

  1. filtrationis filtered off
  2. customthe filtrate is evaporated down
  3. dissolutionThe residue is dissolved in 10 mL ethanol
  4. customThen the product that crystallises out is suction
  5. filtrationfiltered
  6. washwashed

Sources & evidence

ORD record
ord-a6850de313434d4bbf3726e7f136eee8
Source dataset
uspto-grants-2009_03
Patent number
US07511067B2

Reaction notes

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