HCID 68877757, compound → HCID 11198003, compound

Participants

Reaction Steps

5 g of 1-(4-benzyloxy-3-hydroxymethyl-phenyl)-2-(1,1-dimethyl-3-[1,2,4]triazol-4-yl-propylamino)-ethanol acetate are hydrogenated with 0.5 g of palladium on charcoal (5%) in 100 mL methanol. After the theoretically calculated amount of hydrogen has been taken up the catalyst is filtered off and the filtrate is evaporated down. The residue is dissolved in 10 mL ethanol and seeded. Then the product that crystallises out is suction filtered and washed. Yield: 3.2 g (74%, acetate); m.p.=125-127° C.

Provenance & Evidence