反应详情

1.65 g (72 mmol) of sodium are dissolved in 80 mL ethanol. 8.89 g (72 mmol) of ethylacetimidate hydrochloride in 160 mL ethanol are added at ambient temperature and the precipitated sodium chloride is filtered off. The filtrate is combined with 6.00 g (40 mmol) 4-methyl-benzoic acid hydrazide and stirred overnight. The reaction mixture is evaporated down and cooled. The precipitated solid is filtered off and washed with cold ethanol and diethyl ether (5.7 g of white solid). A further 1.2 g of solid are obtained from the filtrate after the removal of the solvent by distillation and recrystallisation from ethanol. Yield: 6.93 g (91%); mass spectroscopy [M+H]+=192.

1. filtrationthe precipitated sodium chloride is filtered off
2. customThe reaction mixture is evaporated down
3. temperaturecooled
4. filtrationThe precipitated solid is filtered off
5. washwashed with cold ethanol and diethyl ether (5.7 g of white solid)