Trifluoroacetic acid → HCID 59754201, compound

HRID 1787850Notes

Reaction equation

HRID 1787850 reaction equation
FC(F)(F)C(O)=O.[CH3:8][C:9]([NH:26]C(=O)OC(C)(C)C)([CH3:25])[CH2:10][CH2:11][N:12]1[C:16]([CH3:17])=[N:15][C:14]([C:18]2[CH:23]=[CH:22][C:21]([CH3:24])=[CH:20][CH:19]=2)=[N:13]1>ClCCl>[CH3:25][C:9]([NH2:26])([CH3:8])[CH2:10][CH2:11][N:12]1[C:16]([CH3:17])=[N:15][C:14]([C:18]2[CH:19]=[CH:20][C:21]([CH3:24])=[CH:22][CH:23]=2)=[N:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 69538809Tert-butyl [1,1-dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propyl]-carbamate

Product 1

HCID 59754201HCID 59754201, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A total of 11 mL trifluoroacetic acid are added dropwise to a solution of 2.97 g (8.3 mmol) of tert.butyl [1,1-dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propyl]-carbamate in 80 mL dichloromethane and the mixture is stirred overnight at ambient temperature. The solvent is distilled off and the residue is combined with diethyl ether and stirred. The precipitated solid is filtered off and washed. Yield: 2.11 g (68%, trifluoroacetate); mass spectroscopy [M+H]+=259.

Workup

  1. distillationThe solvent is distilled off
  2. stirringstirred
  3. filtrationThe precipitated solid is filtered off
  4. washwashed

Sources & evidence

ORD record
ord-b09313c7b74d4df39d251089e8546b43
Source dataset
uspto-grants-2009_03
Patent number
US07511067B2

Reaction notes

Loading…