1,1-Dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propylamine → 4-{2-[1,1-Dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propylamino]-1-hydroxy-ethyl}-2-hydroxymethyl-phenol

HRID 1787854Notes

Reaction equation

HRID 1787854 reaction equation
C([O:8][C:9]1[CH:18]=[CH:17][C:16]([C:19](=[O:25])[CH:20](OCC)O)=[CH:15][C:10]=1[C:11]([O:13]C)=O)C1C=CC=CC=1.[CH3:26][C:27]([NH2:44])([CH3:43])[CH2:28][CH2:29][N:30]1[C:34]([CH3:35])=[N:33][C:32]([C:36]2[CH:41]=[CH:40][C:39]([CH3:42])=[CH:38][CH:37]=2)=[N:31]1>>[CH3:43][C:27]([NH:44][CH2:20][CH:19]([C:16]1[CH:17]=[CH:18][C:9]([OH:8])=[C:10]([CH2:11][OH:13])[CH:15]=1)[OH:25])([CH3:26])[CH2:28][CH2:29][N:30]1[C:34]([CH3:35])=[N:33][C:32]([C:36]2[CH:37]=[CH:38][C:39]([CH3:42])=[CH:40][CH:41]=2)=[N:31]1

Participants

3

Reactant 2

HCID 597542011,1-Dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propylamineHCID 68858509Methyl benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate

Product 1

HCID 576025164-{2-[1,1-Dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propylamino]-1-hydroxy-ethyl}-2-hydroxymethyl-phenol

Procedure

The compound is prepared analogously to the general working method A from 241 mg (0.7 mmol) of methyl 2-benzyloxy-5-(2-ethoxy-2-hydroxy-acetyl)-benzoate and 181 mg (0.7 mmol) of 1,1-dimethyl-3-(5-methyl-3-p-tolyl-[1,2,4]triazol-1-yl)-propylamine.

Sources & evidence

ORD record
ord-5e6f2fd3a3bf42e88505fcf3d36a1220
Source dataset
uspto-grants-2009_03
Patent number
US07511067B2

Reaction notes

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