HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 3-Amino-N-(4-chlorophenyl)pyridine-4-carboxamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 3-(N-tert-Butoxycarbonylamino)-N-(4-chlorophenyl)-pyridine-4-carboxamide | HCID 57602463 | — |
| Product | 3-Amino-N-(4-chlorophenyl)pyridine-4-carboxamide | HCID 18376704 | 93.2% |
Reaction Steps
To 3-(N-tert-butoxycarbonylamino)-N-(4-chlorophenyl)-pyridine-4-carboxamide (552 mg, 1.59 mmol) was added trifluoroacetic acid (3 mL, 38.95 mmol). After stirring for 10 min, the reaction mixture was concentrated, diluted with CH2Cl2, washed with satd Na2CO3, dried (Na2SO4) and concentrated to give the title compound (367 mg, 93%) as a pale yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511066B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-3c0ec90aa0e64da095384d499776ad82 |
| Source note | uspto-grants-2009_03 |