HRID1787915

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2777610

methyl 4-aminothiophene-3-carboxylate

C6H7NO2S

结构：CN(C)c1ccc(C(=O)O)c(OC2CCN(C(=O)OC(C)(C)C)CC2)c1

HCID57602436

未命名化合物

结构：COC(=O)c1cscc1NC(=O)c1ccc(N(C)C)cc1OC1CCN(OC(C)(C)C)C(=C=O)C1

HCID86610259

未命名化合物

PRODUCTS

生成物

结构：COC(=O)c1cscc1NC(=O)c1ccc(N(C)C)cc1OC1CCN(C(=O)OC(C)(C)C)CC1

HCID57602454

未命名化合物

收率 51%

PROCEDURE

实验过程

Using methods substantially equivalent to those described in Example 12-C, methyl 4-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(dimethylamino)benzoylamino]-thiophene-3-carboxylate was prepared in a 51% yield from 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(dimethyl-amino)benzoic acid and methyl 4-aminothiophene-3-carboxylate.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ca0abe26feb74a2bbda23271876d02b4
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07511066B2
来源说明: uspto-grants-2009_03

反应 SMILES

C(O[N:6]1[CH2:11][CH2:10][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]([CH3:33])[CH3:32])[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[C:19]([C:23]([O:25][CH3:26])=[O:24])=[CH:20][S:21][CH:22]=2)=[O:16])[CH2:8][C:7]1=C=O)(C)(C)C.[C:36]([O:40][C:41](N1CCC(OC2C=C(N(C)C)C=CC=2C(O)=O)CC1)=[O:42])([CH3:39])([CH3:38])[CH3:37].NC1C(C(OC)=O)=CSC=1>>[C:36]([O:40][C:41]([N:6]1[CH2:7][CH2:8][CH:9]([O:12][C:13]2[CH:30]=[C:29]([N:31]([CH3:33])[CH3:32])[CH:28]=[CH:27][C:14]=2[C:15]([NH:17][C:18]2[C:19]([C:23]([O:25][CH3:26])=[O:24])=[CH:20][S:21][CH:22]=2)=[O:16])[CH2:10][CH2:11]1)=[O:42])([CH3:39])([CH3:38])[CH3:37]