HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methyl 4-aminothiophene-3-carboxylate → Methyl 4-[2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(dimethylamino)benzoylamino]thiophene-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methyl 4-aminothiophene-3-carboxylate | HCID 2777610 | — |
| Reactant | 2-(1-Tert-butoxycarbonylpiperidin-4-yloxy)-4-(dimethyl-amino)benzoic acid | HCID 57602436 | — |
| Reactant | Methyl 4-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(dimethylamino)benzoylamino]-thiophene-3-carboxylate | HCID 86610259 | — |
| Product | Methyl 4-[2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(dimethylamino)benzoylamino]thiophene-3-carboxylate | HCID 57602454 | 51% |
Reaction Steps
Using methods substantially equivalent to those described in Example 12-C, methyl 4-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(dimethylamino)benzoylamino]-thiophene-3-carboxylate was prepared in a 51% yield from 2-(1-tert-butoxycarbonylpiperidin-4-yloxy)-4-(dimethyl-amino)benzoic acid and methyl 4-aminothiophene-3-carboxylate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511066B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-ca0abe26feb74a2bbda23271876d02b4 |
| Source note | uspto-grants-2009_03 |