Dichloromethane → HCID 57602494, compound

HRID 1787922Notes

Reaction equation

HRID 1787922 reaction equation
C([NH:8][CH2:9][CH2:10][O:11][C:12]1[CH:35]=[C:34]([CH:36]([CH3:38])[CH3:37])[CH:33]=[CH:32][C:13]=1[CH2:14][NH:15][C:16]1[C:21]([C:22]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)=[O:23])=[CH:20][CH:19]=[CH:18][N:17]=1)(OC(C)(C)C)=O.C(Cl)Cl>FC(F)(F)C(O)=O>[NH2:8][CH2:9][CH2:10][O:11][C:12]1[CH:35]=[C:34]([CH:36]([CH3:38])[CH3:37])[CH:33]=[CH:32][C:13]=1[CH2:14][NH:15][C:16]1[C:21]([C:22]([NH:24][C:25]2[CH:30]=[CH:29][C:28]([Cl:31])=[CH:27][CH:26]=2)=[O:23])=[CH:20][CH:19]=[CH:18][N:17]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 57602497HCID 57602497, compound

Product 1

HCID 57602494HCID 57602494, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

2-[2-(N-Boc-Aminoethoxy)-4-isopropylbenzylamino]-N-(4-chlorophenyl)pyridine-3-carboxamide (0.02 g, 0.04 mmol) was dissolved in 2 mL of a 1:3 mixture of trifluoroacetic aicd:methylene chloride. The reaction mixture was stirred at room temperature for 30 min. The solvent was removed, and the material was purified by ion exchange chromatography to afford the title compound (0.014 g, 88%) as the free base.

Workup

  1. customThe solvent was removed
  2. customthe material was purified by ion exchange chromatography

Sources & evidence

ORD record
ord-ef4ebcbafe59483fa610a6277a58bc51
Source dataset
uspto-grants-2009_03
Patent number
US07511066B2

Reaction notes

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