反应详情

To a stirring suspension of 4-(Boc-amino)pyridine-3-carboxylic acid (1.04 g, 4.37 mmol) in methanol (3.5 mL) was added a 2 M solution of (trimethylsilyl)diazomethane in hexanes (3.5 mL, 7 mmol). After 15 min, acetic acid was added and the solvents were removed in vacuo. The residue was chromatographed over silica gel, eluting with a step gradient of 20% ethyl acetate in hexanes through 70% ethyl acetate in hexanes. The product containing fractions were combined and concentrated in vacuo to give the title compound (0.894 g, 81%) as a white solid.

1. customthe solvents were removed in vacuo
2. customThe residue was chromatographed over silica gel
3. washeluting with a step gradient of 20% ethyl acetate in hexanes through 70% ethyl acetate in hexanes
4. additionThe product containing fractions
5. concentrationconcentrated in vacuo