HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrahydrofuran → [2-Amino-5(4-methoxybenzoyl)phenyl](3-chlorophenyl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrahydrofuran | HCID 8028 | — |
| Reactant | [3-(3-Chlorophenyl)-2,1-benzisoxazol-5-yl](4-methoxyphenyl)-methanone | HCID 17976096 | — |
| Solvent | Water | HCID 962 | — |
| Product | [2-Amino-5(4-methoxybenzoyl)phenyl](3-chlorophenyl)-methanone | HCID 17976112 | 104.6% |
Reaction Steps
Intermediate 10 (0.0536 mol) was added at room temperature to THF (200 ml). TiCl3 15% in water (120 ml) was added dropwise at room temperature. The mixture was stirred at room temperature for 3 hours, poured out into ice water and extracted with DCM. The organic layer was separated, washed with K2CO3 10% then with water, dried (MgSO4), filtered and the solvent was evaporated, yielding 20.5 g (quantitative) of [2-amino-5(4-methoxybenzoyl)phenyl](3-chlorophenyl)-methanone (intermediate 11).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511138B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-caaed9f827414c17971404255f2117a8 |
| Source note | uspto-grants-2009_03 |