反应详情

Intermediate 10 (0.0536 mol) was added at room temperature to THF (200 ml). TiCl3 15% in water (120 ml) was added dropwise at room temperature. The mixture was stirred at room temperature for 3 hours, poured out into ice water and extracted with DCM. The organic layer was separated, washed with K2CO3 10% then with water, dried (MgSO4), filtered and the solvent was evaporated, yielding 20.5 g (quantitative) of [2-amino-5(4-methoxybenzoyl)phenyl](3-chlorophenyl)-methanone (intermediate 11).

1. extractionextracted with DCM
2. customThe organic layer was separated
3. washwashed with K2CO3 10%
4. dry with materialwith water, dried (MgSO4)
5. filtrationfiltered
6. customthe solvent was evaporated