反应详情

5,6-Methylenedioxy-3-phenyl-1H-indene-2-carboxylate ethyl ester (3 g, 9.73 mmol) was dissolved in 1,4-dioxane. Selenium dioxide (10.8 g, 97.3 mmol) was added thereto and the reaction mixture was refluxed while stirring for 1 day, followed by cooling. The solution obtained after filtering residual solid selenium dioxide was combined with 1M sodium bicarbonate, and extracted with ether/water. The extract was dried over anhydrous magnesium sulfate, concentrated, and the resulting residue was purified by column chromatography to obtain 5,6-methylenedioxy-1-oxo-3-phenyl-1H-indene-2-carboxylate ethyl ester (2.18 g, yield 70%).

1. temperaturethe reaction mixture was refluxed
2. temperatureby cooling
3. customThe solution obtained
4. filtrationafter filtering residual solid selenium dioxide
5. extractionextracted with ether/water
6. dry with materialThe extract was dried over anhydrous magnesium sulfate
7. concentrationconcentrated
8. customthe resulting residue was purified by column chromatography