反应详情

温度

40 °C

In a dry 2-necked, round bottomed flask, equipped with a magnetic stirrer and fixed with a separatory funnel, containing 9.35 ml (128 mmol) of thionyl chloride, and a water condenser, is placed 24.90 ml (80 mmol) of linoleic acid. Addition of the thionyl chloride is completed with heating to about 40° C. over the course of about 40 minutes. When addition of the thionyl chloride is complete the mixture is heated and stirred for an additional 50 minutes. The water condenser is then replaced with a distillation side arm condenser and the crude mixture is distilled. The crude distillate in the receiving flask is then fractionally distilled to obtain the acyl chloride, (9Z,12Z)-octadeca-9,12-dienoyl chloride.

1. customIn a dry 2-necked, round bottomed flask, equipped with a magnetic stirrer
2. customfixed with a separatory funnel
3. temperatureis heated
4. distillationthe crude mixture is distilled
5. distillationThe crude distillate in the receiving flask is then fractionally distilled