Creatine → Potassium 2-(1-methylguanidino)acetate

HRID 1788317Notes

Reaction equation

HRID 1788317 reaction equation
[O:1]=[C:2]([CH2:4][N:5]([C:7](=[NH:9])[NH2:8])[CH3:6])[OH:3].[OH-].[K+:11]>O>[CH3:6][N:5]([CH2:4][C:2]([O-:3])=[O:1])[C:7]([NH2:9])=[NH:8].[K+:11]

Participants

4

Reactant 2

HCID 586CreatineHCID 14797Potassium Hydroxide

Product 1

HCID 59641369Potassium 2-(1-methylguanidino)acetate

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Separately, in a single-necked, round bottomed flask, equipped with a magnetic stirrer, 7.87 g (60 mmol) of creatine is dissolved in 600 ml of water. To this is added 72 ml of 1M potassium hydroxide with vigorous stirring, until heat production ceases. At this point the water is removed by evaporation to yield the carboxylate salt, potassium 2-(1-methylguanidino)acetate, shown below.

Workup

  1. customSeparately, in a single-necked, round bottomed flask, equipped with a magnetic stirrer
  2. temperatureuntil heat production ceases
  3. customAt this point the water is removed by evaporation

Sources & evidence

ORD record
ord-ac017f4279f9458d9339f09d79516c97
Source dataset
uspto-grants-2009_03
Patent number
US07511164B2

Reaction notes

Loading…