反应详情

温度

5 °C

2-Methoxynaphthalene (30.1 g, 0.19 mol) was added to a solution of aluminum chloride (32.9 g, 0.25 mol) in anhydrous nitrobenzene under a nitrogen atmosphere. To the mixture was slowly added dropwise lauryl chloride (41.6 g, 0.19 mol) at 10-13° C. over 15 minutes. The resulting mixture was stirred at 5° C. for 2 hours and at room temperature for 12 hours. The reaction mixture was poured into 300 ml of 3M HCl at 0° C., extracted with chloroform, and sufficiently washed with brine. The solvents were removed by evaporation under reduced pressure. The residue was dissolved in chloroform and washed with 0.1M NaOH. The mixture was evaporated to remove the chloroform, followed by recrystallization from ethanol to give the title compound (41.5 g, yield: 64.2%).

1. extractionextracted with chloroform
2. washsufficiently washed with brine
3. customThe solvents were removed by evaporation under reduced pressure
4. dissolutionThe residue was dissolved in chloroform
5. washwashed with 0.1M NaOH
6. customThe mixture was evaporated
7. customto remove the chloroform
8. customfollowed by recrystallization from ethanol