反应详情

温度

25 °C

To a solution of the product of Example 44A (2.16 g, 9.51 mmol) in CHCl3 (8 mL) was added, with ice cooling, pyrrolidine (4.05 g, 57.04 mmol). The mixture was stirred at 25° C. for 2 hrs, then concentrated in vacuo. The residue was dissolved in toluene, washed with HCl and water, dried (Na2SO4) and concentrated. The resulting oil was crystallized from hexane and chromatographed (CH2Cl2) to yield the title compound (1.92 g), m.p. 101-102° C.

1. concentrationconcentrated in vacuo
2. dissolutionThe residue was dissolved in toluene
3. washwashed with HCl and water
4. dry with materialdried (Na2SO4)
5. concentrationconcentrated
6. customThe resulting oil was crystallized from hexane
7. customchromatographed (CH2Cl2)