Pyrrolidine → 2-Hydroxy-5-chlorobenzene sulfonyl pyrrolidine

HRID 1788353Notes

Reaction equation

HRID 1788353 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9](Cl)(=[O:11])=[O:10].[NH:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1>C(Cl)(Cl)Cl>[OH:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[S:9]([N:13]1[CH2:17][CH2:16][CH2:15][CH2:14]1)(=[O:11])=[O:10]

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 3043845-Chloro-2-hydroxybenzene-1-sulfonyl chloride

Product 1

HCID 694041512-Hydroxy-5-chlorobenzene sulfonyl pyrrolidineYield 77.1%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Conditions

Temperature
25 °C

Procedure

To a solution of the product of Example 44A (2.16 g, 9.51 mmol) in CHCl3 (8 mL) was added, with ice cooling, pyrrolidine (4.05 g, 57.04 mmol). The mixture was stirred at 25° C. for 2 hrs, then concentrated in vacuo. The residue was dissolved in toluene, washed with HCl and water, dried (Na2SO4) and concentrated. The resulting oil was crystallized from hexane and chromatographed (CH2Cl2) to yield the title compound (1.92 g), m.p. 101-102° C.

Workup

  1. concentrationconcentrated in vacuo
  2. dissolutionThe residue was dissolved in toluene
  3. washwashed with HCl and water
  4. dry with materialdried (Na2SO4)
  5. concentrationconcentrated
  6. customThe resulting oil was crystallized from hexane
  7. customchromatographed (CH2Cl2)

Sources & evidence

ORD record
ord-bb2c04385d94409da80ed51508944315
Source dataset
uspto-grants-2009_03
Patent number
US07511175B2

Reaction notes

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