Ethanol → HCID 68826072, compound

A solution of 1 M diisobutylaluminum hydride in toluene (13.9 mL, 13.9 mmol) was slowly dropped into a cooled (-78° C.) solution of 4-methoxycarbonylmethylene-3-methylpiperidine-1-carboxylic acid t-butyl ester (1.5 g, 5.6 mmol) obtained in the above 1) in tetrahydrofuran (30 mL) under an atmosphere of argon. After dropping, it was stirred for 2 hours at the same temperature. After the reaction was completed, ethanol (8 mL) was added thereto at 0° C. and allowed to warm to room temperature gradually. The reaction mixture was then concentrated under a reduced pressure, treated with an aqueous solution of 20% sodium potassium tartrate (20 mL), and stirred for 30 minutes. After stirring, the solution was extracted with ether, dried over anhydrous sodium sulfate. After drying, it was filtered, and the filtrate was concentrated under a reduced pressure. The residue was subjected to silica gel column chromatography (developing solvent; hexane:ethyl acetate=2:1) to obtain 1.2 g (yield 89.6%) of 4-(2-hydroxyethylidene)-3-methylpiperidine-1-carboxylic acid t-butyl ester. Its physical property is shown below.

1. customat 0° C.
2. concentrationThe reaction mixture was then concentrated under a reduced pressure
3. additiontreated with an aqueous solution of 20% sodium potassium tartrate (20 mL)
4. stirringstirred for 30 minutes
5. stirringAfter stirring
6. extractionthe solution was extracted with ether
7. dry with materialdried over anhydrous sodium sulfate
8. customAfter drying
9. filtrationit was filtered
10. concentrationthe filtrate was concentrated under a reduced pressure

ORD record

ord-bbde1e1a9a2a424bb6d3c71afc2a278f

Source dataset

uspto-grants-2009_03

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US07511144B2