Sodium Hydroxide → 2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid

HRID 1788416노트

반응식

HRID 1788416 반응식
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[C:20]([C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)=[CH:19][CH:18]=[C:17]([C:28]([N:30]3[CH2:34][CH2:33][CH2:32][CH2:31]3)=[O:29])[CH:16]=1)[CH:9]=[CH:8]2)=[O:4].[OH-].[Na+]>CO>[Cl:27][C:24]1[CH:23]=[CH:22][C:21]([C:20]2[C:15]([C:10]3[CH:9]=[CH:8][C:7]4[C:12](=[CH:13][CH:14]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=4)[N:11]=3)=[CH:16][C:17]([C:28]([N:30]3[CH2:31][CH2:32][CH2:33][CH2:34]3)=[O:29])=[CH:18][CH:19]=2)=[CH:26][CH:25]=1

참가 물질

4

반응물 2

HCID 14798Sodium HydroxideHCID 576029372-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid methyl ester

생성물 1

HCID 576029872-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carboxylic acid수율 96%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Compound 23 from the previous step (0.63 mmol) was dissolved in 15 mL methanol, and 5 mL of 1M NaOH were added. The solution was refluxed for 2 hours, then evaporated. The residue was then dissolved in water, acidified with 5 mL of 1M HCl, and the precipitate was filtered off, washed three times with water and dried to yield 276 mg (96%) of Compound 24.

후처리

  1. temperatureThe solution was refluxed for 2 hours
  2. customevaporated
  3. dissolutionThe residue was then dissolved in water
  4. filtrationthe precipitate was filtered off
  5. washwashed three times with water
  6. customdried

출처 및 근거

ORD 기록
ord-1bb067aa9e124cfba1b76803ee35be69
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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