反应详情

Compound 23 from the previous step (0.63 mmol) was dissolved in 15 mL methanol, and 5 mL of 1M NaOH were added. The solution was refluxed for 2 hours, then evaporated. The residue was then dissolved in water, acidified with 5 mL of 1M HCl, and the precipitate was filtered off, washed three times with water and dried to yield 276 mg (96%) of Compound 24.

1. temperatureThe solution was refluxed for 2 hours
2. customevaporated
3. dissolutionThe residue was then dissolved in water
4. filtrationthe precipitate was filtered off
5. washwashed three times with water
6. customdried