4-Cyclohexylamino-3-[(3-phenyl-quinoxaline-6-carbonyl)-amino]-benzoic Acid Ethyl Ester → HCID 57602929, compound

HRID 1788418Notes

Reaction equation

HRID 1788418 reaction equation
[CH2:1]([O:3][C:4](=[O:37])[C:5]1[CH:10]=[CH:9][C:8]([NH:11][CH:12]2[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]2)=[C:7]([NH:18][C:19]([C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[N:27]=[CH:26][C:25](C2C=CC=CC=2)=[N:24]3)=O)[CH:6]=1)[CH3:2]>C(O)(=O)C>[CH2:1]([O:3][C:4]([C:5]1[CH:10]=[CH:9][C:8]2[N:11]([CH:12]3[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13]3)[C:19]([C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[N:27]=[CH:26][C:25]([C:5]3[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=3)=[N:24]4)=[N:18][C:7]=2[CH:6]=1)=[O:37])[CH3:2]

Participants

3

Reactant 1

HCID 576030194-Cyclohexylamino-3-[(3-phenyl-quinoxaline-6-carbonyl)-amino]-benzoic Acid Ethyl Ester

Product 1

HCID 57602929HCID 57602929, compound

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Compound 41 (0.95 mmol) from the previous step was refluxed in 80 mL acetic acid for 3.5 h. The mixture was then evaporated to dryness and dried overnight under high vacuum to yield Compound 42 in quantitative yield. It was not further purified before saponification.

Workup

  1. customThe mixture was then evaporated to dryness
  2. customdried overnight under high vacuum

Sources & evidence

ORD record
ord-d7044bea1cd14d9da16f302f9bea6c67
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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