HRID1788421

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14798

Sodium Hydroxide

HNaO

HCID93032

Glutamic acid dimethyl ester

C7H13NO4

结构：O=C(O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)ccc3c1)n2C1CCCCC1

HCID11213026

未命名化合物

结构：O=C(NC(Cc1c[nH]c2ccc(O)cc12)C(=O)O)c1ccc2c(c1)nc(-c1ccc3nc(-c4cc(C(=O)N5CCCC5)ccc4-c4ccc(Cl)cc4)ccc3c1)n2C1CCCCC1

HCID57623685

未命名化合物

PRODUCTS

生成物

结构：O=C(O)CCC(NC(=O)c1ccc2c(c1)nc(-c1ccc3nc(-c4ccccc4)ccc3c1)n2C1CCCCC1)C(=O)O

HCID5276162

未命名化合物

收率 15%

PROCEDURE

实验过程

Compound 237 was synthesized from Compound 201 as described for Compound 235, using L-glutamic acid dimethylester in place of L-5-hydroxytryptophane. In the 3rd step the protected intermediate was treated with aqueous sodium hydroxide for a 15% yield of the title compound

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-bfe9ed1a60e440c4aca3ac6e6d1cc065
来源数据集: uspto-grants-2009_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07511145B2
来源说明: uspto-grants-2009_03

反应 SMILES

[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16](O)=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:26](=[CH:27][CH:28]=2)[N:25]=[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=[CH:22]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.ClC1C=CC(C2C(C3C=CC4C(=CC=C(C5N(C6CCCCC6)C6C=CC(C(NC(CC7C8C(=CC=C(O)C=8)NC=7)C(O)=O)=O)=CC=6N=5)C=4)N=3)=CC(C(N3CCCC3)=O)=CC=2)=CC=1.C[O:99][C:100](=[O:109])[C@H:101]([CH2:103][CH2:104][C:105]([O:107]C)=[O:106])[NH2:102].[OH-].[Na+]>>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([NH:102][CH:101]([CH2:103][CH2:104][C:105]([OH:107])=[O:106])[C:100]([OH:99])=[O:109])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:26](=[CH:27][CH:28]=2)[N:25]=[C:24]([C:29]2[CH:30]=[CH:31][CH:32]=[CH:33][CH:34]=2)[CH:23]=[CH:22]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1