3-Cyclohexyl-2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acid → 2-[[1-Cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-phenyl-propanoic acid

HRID 1788423Notes

Reaction equation

HRID 1788423 reaction equation
[CH:1]1([CH2:7][CH:8]([NH:12][C:13]([C:15]2[CH:45]=[CH:44][C:18]3[N:19]([CH:38]4[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]4)[C:20]([C:22]4[CH:23]=[C:24]5[C:29](=[CH:30][CH:31]=4)[N:28]=[C:27]([C:32]4[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=4)[CH:26]=[N:25]5)=[N:21][C:17]=3[CH:16]=2)=[O:14])[C:9]([OH:11])=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C1C=CC(C[C@H](NC(OCC2C3C(=CC=CC=3)C3C2=CC=CC=3)=O)C=O)=CC=1>>[CH:38]1([N:19]2[C:18]3[CH:44]=[CH:45][C:15]([C:13]([NH:12][CH:8]([CH2:7][C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[C:9]([OH:11])=[O:10])=[O:14])=[CH:16][C:17]=3[N:21]=[C:20]2[C:22]2[CH:23]=[C:24]3[C:29](=[CH:30][CH:31]=2)[N:28]=[C:27]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH:26]=[N:25]3)[CH2:43][CH2:42][CH2:41][CH2:40][CH2:39]1

Participants

3

Reactant 2

HCID 52761673-Cyclohexyl-2-[[1-cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]propanoic acidHCID 104743759H-Fluoren-9-ylmethyl N-((1S)-1-formyl-2-phenylethyl)carbamate

Product 1

HCID 52761712-[[1-Cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carbonyl]amino]-3-phenyl-propanoic acidYield 44%

Procedure

The general procedure described for Compound 242 was used with Fmoc-Phe Wang resin (167 mg, 0.6 mmol/g), producing 26 mg of the title compound (44% yield). MS: 594.24 (M−H+) HPLC Procedure A, retention time=14.58 min.

Sources & evidence

ORD record
ord-15200b5071cc425b84d0e423c16c6a4f
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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