Acetophenone → 1-Cyclohexyl-2-[2-[3-(pyrrolidine-1-carbonyl)phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid

HRID 1788433노트

반응식

HRID 1788433 반응식
C(OC(=O)C1C=CC(NC2CCCCC2)=C(NC(C2C=C3C(=CC=2)N=C(C2C(C4C=CC(Cl)=CC=4)=CC=C(C(N4CCCC4)=O)C=2)C=C3)=O)C=1)C.ClC1C=CC([C:57]2[C:62]([C:63]3[CH:72]=[CH:71][C:70]4[C:65](=[CH:66][CH:67]=[C:68]([C:73]5[N:77]([CH:78]6[CH2:83][CH2:82][CH2:81][CH2:80][CH2:79]6)[C:76]6[CH:84]=[CH:85][C:86]([C:88]([OH:90])=[O:89])=[CH:87][C:75]=6[N:74]=5)[CH:69]=4)[N:64]=3)=[CH:61][C:60]([C:91]([N:93]3[CH2:97][CH2:96][CH2:95][CH2:94]3)=[O:92])=[CH:59][CH:58]=2)=CC=1.C(C1C=CC=CC=1)(=O)C>>[CH:78]1([N:77]2[C:76]3[CH:84]=[CH:85][C:86]([C:88]([OH:90])=[O:89])=[CH:87][C:75]=3[N:74]=[C:73]2[C:68]2[CH:69]=[C:70]3[C:65](=[CH:66][CH:67]=2)[N:64]=[C:63]([C:62]2[CH:57]=[CH:58][CH:59]=[C:60]([C:91]([N:93]4[CH2:97][CH2:96][CH2:95][CH2:94]4)=[O:92])[CH:61]=2)[CH:72]=[CH:71]3)[CH2:83][CH2:82][CH2:81][CH2:80][CH2:79]1

참가 물질

4

반응물 3

HCID 7410AcetophenoneHCID 111813412-{2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acidHCID 576030893-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester

생성물 1

HCID 52759961-Cyclohexyl-2-[2-[3-(pyrrolidine-1-carbonyl)phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid

실험 절차

The title compound was synthesized in four steps as described for Compound 13, Compound 25, Compound 27 Q=ethyl and Compound 204, respectively, except the product of the previous step was used in the first step, instead of acetophenone.

출처 및 근거

ORD 기록
ord-4b3431549d244b98a38fd0c4ff8b8882
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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