Acetophenone → 1-Cyclohexyl-2-[2-[3-(pyrrolidine-1-carbonyl)phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid

Participants

Role	Name	HCID	Charge
Reactant	Acetophenone	HCID 7410	—
Reactant	2-{2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid	HCID 11181341	—
Reactant	3-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester	HCID 57603089	—
Product	1-Cyclohexyl-2-[2-[3-(pyrrolidine-1-carbonyl)phenyl]-6-quinolyl]benzimidazole-5-carboxylic acid	HCID 5275996	—

Reaction Steps

The title compound was synthesized in four steps as described for Compound 13, Compound 25, Compound 27 Q=ethyl and Compound 204, respectively, except the product of the previous step was used in the first step, instead of acetophenone.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07511145B2
Source dataset	uspto-grants-2009_03
ORD ID	ord-4b3431549d244b98a38fd0c4ff8b8882
Source note	uspto-grants-2009_03