HCID 68919442, compound → HCID 68919304, compound

HRID 1788435Notes

Reaction equation

HRID 1788435 reaction equation
C[O:2][C:3]([C:5]1[CH:6]=[C:7]2[C:12](=[CH:13][CH:14]=1)[N:11]=[C:10]([C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=1[Br:21])[CH:9]=[C:8]2[CH3:22])=[O:4]>O1CCOCC1.[OH-].[Na+]>[Br:21][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][C:15]=1[C:10]1[CH:9]=[C:8]([CH3:22])[C:7]2[C:12](=[CH:13][CH:14]=[C:5]([C:3]([OH:4])=[O:2])[CH:6]=2)[N:11]=1

Participants

4

Reactant 1

HCID 68919442HCID 68919442, compound

Product 1

HCID 68919304HCID 68919304, compound

Reagents, catalysts & solvents 2

HCID 14798Sodium HydroxideSolventHCID 312751,4-DioxaneSolvent

Procedure

Compound 471b (500 mg, 1.4 mmol) was refluxed in a mixture of 15 mL dioxane and 15 mL 1M aqueous NaOH for 1 h then it was evaporated to dryness, the residue dissolved in 50 mL water and acidified with 1M HCl solution to pH 4. The precipitate was filtered off, washed four times with water and dried. Yield: 361 mg (75%).

Workup

  1. customit was evaporated to dryness
  2. dissolutionthe residue dissolved in 50 mL water
  3. filtrationThe precipitate was filtered off
  4. washwashed four times with water
  5. customdried

Sources & evidence

ORD record
ord-8c1876e49ccd4ba6b93659497178e00f
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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