2-Bromoethyl methyl ether → HCID 5276000, compound

HRID 1788445Notes

Reaction equation

HRID 1788445 reaction equation
[Cl:1][C:2]1[CH:46]=[CH:45][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9]([O:40][CH2:41][CH2:42][O:43]C)=[CH:8][CH:7]=2)=[CH:4][CH:3]=1.BrCC([N:51]1[CH2:55][CH2:54][CH2:53][CH2:52]1)=O.BrCCOC>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]2[C:11]([C:12]3[CH:21]=[CH:20][C:19]4[C:14](=[CH:15][CH:16]=[C:17]([C:22]5[N:26]([CH:27]6[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]6)[C:25]6[CH:33]=[CH:34][C:35]([C:37]([OH:39])=[O:38])=[CH:36][C:24]=6[N:23]=5)[CH:18]=4)[N:13]=3)=[CH:10][C:9]([O:40][CH2:41][C:42](=[O:43])[N:51]3[CH2:55][CH2:54][CH2:53][CH2:52]3)=[CH:8][CH:7]=2)=[CH:45][CH:46]=1

Participants

4

Reactant 3

HCID 809722-Bromoethyl methyl etherHCID 5276094HCID 5276094, compoundHCID 111061881-(Bromoacetyl)pyrrolidine

Product 1

HCID 5276000HCID 5276000, compound

Procedure

The title compound was synthesized as described for Compound 475, except 2-bromo-1-pyrrolidin-1-yl-ethanone was used for alkylation instead of 1-bromo-2-methoxy ethane.

Sources & evidence

ORD record
ord-201e1ca4bfb84b008c056857988a2b0e
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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