Sodium Hydroxide → 6-(5-Carboxy-1-cyclohexyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid

HRID 1788457Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1788457
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([O:18]CC)=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:21]2[CH:22]=[C:23]3[C:28](=[CH:29][CH:30]=2)[N:27]=[C:26]([C:31]([OH:33])=[O:32])[CH:25]=[CH:24]3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[OH-].[Na+]>CO>[C:16]([C:14]1[CH:13]=[CH:12][C:11]2[N:7]([CH:1]3[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]3)[C:8]([C:21]3[CH:22]=[C:23]4[C:28](=[CH:29][CH:30]=3)[N:27]=[C:26]([C:31]([OH:33])=[O:32])[CH:25]=[CH:24]4)=[N:9][C:10]=2[CH:15]=1)([OH:18])=[O:17]

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 576029956-(1-Cyclohexyl-5-ethoxycarbonyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid

Produkt 1

HCID 112470096-(5-Carboxy-1-cyclohexyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

A solution of 90 mg (0.2 mmol) of Compound 402a and 1 mL 2 N aq. NaOH in 4 mL MeOH was heated overnight at 55° C. The solvent was evaporated, the residue was dissolved in H2O and neutralized. The precipitate was filtered, washed with H2O and dried. The product was purified by HPLC to yield 34 mg.

Aufarbeitung

  1. customThe solvent was evaporated
  2. dissolutionthe residue was dissolved in H2O
  3. filtrationThe precipitate was filtered
  4. washwashed with H2O
  5. customdried
  6. customThe product was purified by HPLC
  7. customto yield 34 mg

Quellen und Nachweise

ORD-Eintrag
ord-8a2b9777bb2f40ab8aa7be56f19d678a
Quelldatensatz
uspto-grants-2009_03
Patentnummer
US07511145B2

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