HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → 6-(5-Carboxy-1-cyclohexyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 6-(1-Cyclohexyl-5-ethoxycarbonyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid | HCID 57602995 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 6-(5-Carboxy-1-cyclohexyl-1H-benzimidazol-2-yl)quinoline-2-carboxylic Acid | HCID 11247009 | — |
Reaction Steps
A solution of 90 mg (0.2 mmol) of Compound 402a and 1 mL 2 N aq. NaOH in 4 mL MeOH was heated overnight at 55° C. The solvent was evaporated, the residue was dissolved in H2O and neutralized. The precipitate was filtered, washed with H2O and dried. The product was purified by HPLC to yield 34 mg.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-8a2b9777bb2f40ab8aa7be56f19d678a |
| Source note | uspto-grants-2009_03 |