Phenylacetaldehyde → HCID 68924560, compound

HRID 1788466Notes

Reaction equation

HRID 1788466 reaction equation
C1([C:7]2[CH:16]=[CH:15][C:14]3[C:9](=[CH:10][C:11]([C:17]([OH:19])=[O:18])=[CH:12][CH:13]=3)[N:8]=2)C=CC=CC=1.COC(=O)[C:23]1[CH:28]=[CH:27][C:26](C=O)=[C:25](N)[CH:24]=1.C1(CC=O)C=CC=CC=1>>[C:23]1([C:16]2[CH:7]=[N:8][C:9]3[C:14]([CH:15]=2)=[CH:13][CH:12]=[C:11]([C:17]([OH:19])=[O:18])[CH:10]=3)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 998PhenylacetaldehydeHCID 159468712-Phenylquinoline-7-carboxylic acidHCID 18412577Methyl 3-amino-4-formylbenzoate

Product 1

HCID 68924560HCID 68924560, compoundYield 87%

Procedure

Following the same reaction procedure and workup for Compound 405f, 500 mg (2.8 mmol) of Compound 53 was reacted with 340 mg (2.8 mmol) phenylacetaldehyde to produce 603 mg (87% yield) of the title intermediate.

Sources & evidence

ORD record
ord-51e6b8b87432486790abfede31b72046
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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