Acetic Acid → HCID 5275977, compound

HRID 1788467Notes

Reaction equation

HRID 1788467 reaction equation
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:28]=[C:27]3[C:22]([CH:23]=[CH:24][C:25](C4C=CC=CC=4)=[N:26]3)=[CH:21][CH:20]=2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[C:35](O)(=O)[CH3:36].[OH-].[Na+]>CCO>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:28]=[C:27]3[C:22]([CH:23]=[C:24]([C:36]4[CH:35]=[CH:3][CH:2]=[CH:1][CH:6]=4)[CH:25]=[N:26]3)=[CH:21][CH:20]=2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

5

Reactant 3

HCID 176Acetic AcidHCID 14798Sodium HydroxideHCID 5276026HCID 5276026, compound

Product 1

HCID 5275977HCID 5275977, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Following the same reaction procedure and workup as for Compound 405, 450 mg (0.9 mmol) of the product from the previous step was cyclized with 40 mL acetic acid and saponified with 35 mL EtOH and 7 mL 1M NaOH to produce 70 mg (17% yield) of the title compound.

Sources & evidence

ORD record
ord-7b5b89fcdf564fe386e02f5424db8de5
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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