HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-Amino-4-methylcoumarin → 1-Cyclohexyl-2-(2-phenyl-quinoxalin-6-yl)-1H-benzoimidazole-5-carboxylic Acid (4-methyl-2-oxo-2H-chromen-7-yl)-amide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-Amino-4-methylcoumarin | HCID 92249 | — |
| Reactant | 1-cyclohexyl-2-(2-phenyl-quinoxalin-6-yl)-1H-benzoimidazole-5-carboxylic Acid morpholin-4-ylamide | HCID 57603045 | — |
| Product | 1-Cyclohexyl-2-(2-phenyl-quinoxalin-6-yl)-1H-benzoimidazole-5-carboxylic Acid (4-methyl-2-oxo-2H-chromen-7-yl)-amide | HCID 57603151 | 27% |
Reaction Steps
The general procedure described for Compound 574 was used with 7-Amino-4-methyl-chromen-2-one (17.5 mg), producing 8 mg of the title compound (27% yield). MS: 606.29 (M+H+) HPLC Procedure A, retention time=19.22 min.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-4fd734490f3241b4926853d768dbdc08 |
| Source note | uspto-grants-2009_03 |