Methanol → HCID 5275976, compound

HRID 1788472Notes

Reaction equation

HRID 1788472 reaction equation
[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:26](=[CH:27][CH:28]=2)[N:25]=[C:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH:23]=N3)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH3:35]O>[Pt]=O>[CH:1]1([N:7]2[C:11]3[CH:12]=[CH:13][C:14]([C:16]([OH:18])=[O:17])=[CH:15][C:10]=3[N:9]=[C:8]2[C:19]2[CH:20]=[C:21]3[C:26](=[CH:27][CH:28]=2)[NH:25][CH:24]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][CH:30]=2)[CH2:23][CH2:35]3)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1

Participants

4

Reactant 2

HCID 887MethanolHCID 52759721-Cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid

Product 1

HCID 5275976HCID 5275976, compoundYield 37%

Reagents, catalysts & solvents 1

HCID 82844Platinum oxide (PtO)Catalyst

Procedure

A solution of Compound 203 (100 mg, 0.23 mmol) and platinum oxide (12 mg, 0.048 mmol) in methanol (5 mL) was hydrogenated at 40 psi for 3 h. The reaction was evaporated to dryness, and purified via HPLC. The resulting compound was then converted to the HCl salt using the standard method, yielding 40 mg (37% yield) of the title compound.

Workup

  1. customThe reaction was evaporated to dryness
  2. custompurified via HPLC

Sources & evidence

ORD record
ord-69d0562ddf334b968cb7cf8b9f8bccaf
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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