HuagongsheHuagongshe Chemistry Print Report · For research reference only
Methanol → HCID 5275976, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Methanol | HCID 887 | — |
| Reactant | 1-Cyclohexyl-2-(2-phenylquinoxalin-6-yl)benzimidazole-5-carboxylic acid | HCID 5275972 | — |
| Catalyst | Platinum oxide (PtO) | HCID 82844 | — |
| Product | HCID 5275976 | HCID 5275976 | 37% |
Reaction Steps
A solution of Compound 203 (100 mg, 0.23 mmol) and platinum oxide (12 mg, 0.048 mmol) in methanol (5 mL) was hydrogenated at 40 psi for 3 h. The reaction was evaporated to dryness, and purified via HPLC. The resulting compound was then converted to the HCl salt using the standard method, yielding 40 mg (37% yield) of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-69d0562ddf334b968cb7cf8b9f8bccaf |
| Source note | uspto-grants-2009_03 |