Potassium Hydroxide → HCID 5276017, compound

HRID 1788500Notes

Reaction equation

HRID 1788500 reaction equation
BrC1C=CC(O)=C(C2C=[CH:16][C:15]3[C:10](=[CH:11][CH:12]=[C:13]([C:18]4[N:22]([CH:23]5[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]5)[C:21]5[CH:29]=[CH:30][C:31]([C:33]([OH:35])=[O:34])=[CH:32][C:20]=5[N:19]=4)[CH:14]=3)[N:9]=2)C=1.[Br:37][C:38]1[C:46]2[O:45][C:44]([C:47](=O)[CH3:48])=[CH:43][C:42]=2[CH:41]=[C:40]([O:50][CH3:51])[CH:39]=1.[OH-].[K+]>C(O)C>[Br:37][C:38]1[C:46]2[O:45][C:44]([C:47]3[CH:48]=[CH:16][C:15]4[C:10](=[CH:11][CH:12]=[C:13]([C:18]5[N:22]([CH:23]6[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28]6)[C:21]6[CH:29]=[CH:30][C:31]([C:33]([OH:35])=[O:34])=[CH:32][C:20]=6[N:19]=5)[CH:14]=4)[N:9]=3)=[CH:43][C:42]=2[CH:41]=[C:40]([O:50][CH3:51])[CH:39]=1

Participants

5

Reactant 3

HCID 14797Potassium HydroxideHCID 27645201-(7-Bromo-5-methoxy-1-benzofuran-2-yl)ethan-1-oneHCID 52759802-[2-(5-Bromo-2-hydroxy-phenyl)-6-quinolyl]-1-cyclohexyl-benzimidazole-5-carboxylic acid

Product 1

HCID 5276017HCID 5276017, compoundYield 17%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Procedure

Following the procedure and workup for Compound 354, Compound 354e (100 mg, 0.256 mmol) was reacted with 1-(7-bromo-5-methoxy-benzofuran-2-yl)-ethanone (0.256 mmol) in ethanol (2 mL) using 10% w/v KOH in ethanol (506 μL, 0.64 mmol) to produce the title compound, 17% yield).

Sources & evidence

ORD record
ord-daddd1a164d64e08853823a139fc8a8c
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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