反应详情

温度

55 °C

Compound 477d (0.139 g, 0.25 mmol) was dissolved in MeOH (3 mL) and 2 N aqueous NaOH (1.5 mL) was added. The mixture was stirred at 55° C. for 2 h and then neutralized with 5 N HCl to pH 3 at 0° C. The precipitates formed was collected by filtration and purified by RP HPLC (15% of buffer B to 95% of buffer B) to give the title compound. Yield 96%.

1. customThe precipitates formed
2. filtrationwas collected by filtration
3. custompurified by RP HPLC (15% of buffer B to 95% of buffer B)