4-Chloro-3-nitrobenzoic acid → 2-[2-[2-(4-Chlorophenyl)-5-methoxy-phenyl]-6-quinolyl]-1-(4-methylcyclohexyl)benzimidazole-5-carboxylic acid

HRID 1788565Notes

Reaction equation

HRID 1788565 reaction equation
Cl[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=1[N+:11]([O-])=O.C[C@H]1CC[C@H](N)CC1.[Cl:22][C:23]1[CH:60]=[CH:59][C:26]([C:27]2[C:32]([C:33]3[CH:42]=[CH:41][C:40]4[C:35](=[CH:36][CH:37]=[C:38]([C:43]5[N:47](CC)[C:46]6[CH:50]=[CH:51][C:52]([C:54](O)=O)=[CH:53][C:45]=6N=5)[CH:39]=4)[N:34]=3)=[CH:31][C:30]([O:57][CH3:58])=[CH:29][CH:28]=2)=[CH:25][CH:24]=1>>[Cl:22][C:23]1[CH:60]=[CH:59][C:26]([C:27]2[C:32]([C:33]3[CH:42]=[CH:41][C:40]4[C:35](=[CH:36][CH:37]=[C:38]([C:43]5[N:47]([CH:46]6[CH2:45][CH2:53][CH:52]([CH3:54])[CH2:51][CH2:50]6)[C:2]6[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[CH:4][C:3]=6[N:11]=5)[CH:39]=4)[N:34]=3)=[CH:31][C:30]([O:57][CH3:58])=[CH:29][CH:28]=2)=[CH:25][CH:24]=1

Participants

4

Reactant 3

HCID 73204-Chloro-3-nitrobenzoic acidHCID 52761842-[2-[2-(4-Chlorophenyl)-5-methoxy-phenyl]-6-quinolyl]-1-ethyl-benzimidazole-5-carboxylic acidHCID 178461305HCID 178461305, compound

Product 1

HCID 52761312-[2-[2-(4-Chlorophenyl)-5-methoxy-phenyl]-6-quinolyl]-1-(4-methylcyclohexyl)benzimidazole-5-carboxylic acid

Procedure

The title compound was prepared from Resin 534a and a mixture of cis and trans 4-methylcyclohexyl-amine according to the procedure described in the preparation of Compound 534.

Sources & evidence

ORD record
ord-85aae62cdf464e669bee6474f376901c
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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