1H-Imidazole-1-propanamine → HCID 5276071, compound

HRID 1788577Notes

Reaction equation

HRID 1788577 reaction equation
C([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=[C:16]4Cl)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.C1(N2C3C=CC(C(O)=O)=CC=3N=C2C2C=C3C(=CC=2)N=C(C2C=CC=CC=2)C=C3N(C)C)CCCCC1.[N:75]1([CH2:80][CH2:81][CH2:82][NH2:83])[CH:79]=[CH:78][N:77]=[CH:76]1>>[CH:30]1([N:10]2[C:9]3[CH:36]=[CH:37][C:6]([C:4]([OH:3])=[O:5])=[CH:7][C:8]=3[N:12]=[C:11]2[C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[C:16]3[NH:83][CH2:82][CH2:81][CH2:80][N:75]2[CH:79]=[CH:78][N:77]=[CH:76]2)[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]1

Participants

4

Reactant 3

HCID 787361H-Imidazole-1-propanamineHCID 52761001-Cyclohexyl-2-[4-(dimethylamino)-2-phenyl-6-quinolyl]benzimidazole-5-carboxylic acidHCID 68924249HCID 68924249, compound

Product 1

HCID 5276071HCID 5276071, compound

Procedure

In this reaction 102 mg (0.2 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester were used in the same reaction sequence as that used for Compound 481. The nucleophile used was 3-imidazol-1-yl-propylamine. Yield: 31 mg.

Sources & evidence

ORD record
ord-6c72001d47fa4633b55549ce9ad7c27d
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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