Acetophenone → 2-(2-Benzhydryl-6-quinolyl)-1-cyclohexyl-benzimidazole-5-carboxylic acid

HRID 1788588노트

반응식

HRID 1788588 반응식
C(OC(=O)C1C=CC(NC2CCCCC2)=C(NC(C2C=C3C(=CC=2)N=[C:26]([C:31]2[C:36]([C:37]4[CH:42]=[CH:41][C:40](Cl)=[CH:39][CH:38]=4)=[CH:35][CH:34]=[C:33](C(N4CCCC4)=O)[CH:32]=2)C=C3)=O)C=1)C.ClC1C=CC(C2C([C:63]3[CH:72]=[CH:71][C:70]4[C:65](=[CH:66][CH:67]=[C:68]([C:73]5[N:77]([CH:78]6[CH2:83][CH2:82][CH2:81][CH2:80][CH2:79]6)[C:76]6[CH:84]=[CH:85][C:86]([C:88]([OH:90])=[O:89])=[CH:87][C:75]=6[N:74]=5)[CH:69]=4)[N:64]=3)=CC(C(N3CCCC3)=O)=CC=2)=CC=1.C1(C(C2C=CC=CC=2)C(C)=O)C=CC=CC=1.C(C1C=CC=CC=1)(=O)C>>[CH:36]([C:63]1[CH:72]=[CH:71][C:70]2[C:65](=[CH:66][CH:67]=[C:68]([C:73]3[N:77]([CH:78]4[CH2:83][CH2:82][CH2:81][CH2:80][CH2:79]4)[C:76]4[CH:84]=[CH:85][C:86]([C:88]([OH:90])=[O:89])=[CH:87][C:75]=4[N:74]=3)[CH:69]=2)[N:64]=1)([C:31]1[CH:26]=[CH:35][CH:34]=[CH:33][CH:32]=1)[C:37]1[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=1

참가 물질

5

반응물 4

HCID 7410AcetophenoneHCID 699071,1-DiphenylacetoneHCID 111813412-{2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acidHCID 576030893-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester

생성물 1

HCID 52760762-(2-Benzhydryl-6-quinolyl)-1-cyclohexyl-benzimidazole-5-carboxylic acid

실험 절차

The title compound was synthesized in four steps as described for Compound 13, Compound 25, Compound 27, Q=ethyl and Compound 204, respectively, except 1,1-diphenylacetone was used in the first step, instead of acetophenone.

출처 및 근거

ORD 기록
ord-7165482d1b544f339b673f77c011c5ae
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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