HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetophenone → 2-(2-Benzhydryl-6-quinolyl)-1-cyclohexyl-benzimidazole-5-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetophenone | HCID 7410 | — |
| Reactant | 1,1-Diphenylacetone | HCID 69907 | — |
| Reactant | 2-{2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinolin-6-yl}-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid | HCID 11181341 | — |
| Reactant | 3-({2-[4'-Chloro-4-(pyrrolidine-1-carbonyl)-biphen-2-yl]-quinoline-6-carbonyl}-amino)-4-cyclohexylamino-benzoic acid ethyl ester | HCID 57603089 | — |
| Product | 2-(2-Benzhydryl-6-quinolyl)-1-cyclohexyl-benzimidazole-5-carboxylic acid | HCID 5276076 | — |
Reaction Steps
The title compound was synthesized in four steps as described for Compound 13, Compound 25, Compound 27, Q=ethyl and Compound 204, respectively, except 1,1-diphenylacetone was used in the first step, instead of acetophenone.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07511145B2 |
| Source dataset | uspto-grants-2009_03 |
| ORD ID | ord-7165482d1b544f339b673f77c011c5ae |
| Source note | uspto-grants-2009_03 |