反应详情

A mixture of 1 g (7.84 mmol) of 4-chloroaniline, 0.91 g (15.68 mmol) of acetone, 0.99 g (15.68 mmol) of NaCNBH3, 4 g of MgSO4 in 99 mL anhydrous EtOH and 1 mL AcOH was stirred at room temperature overnight, filtered and the solvent was removed. The residue was dissolved in 50 mL EtOAc, washed with 50 mL H2O, dried (Na2SO4) and evaporated. The residue was purified on silica gel using hexane/EtOAc as eluent to yield 0.86 g colorless oil. MS: 170.08 (M+H+).

1. filtrationfiltered
2. customthe solvent was removed
3. dissolutionThe residue was dissolved in 50 mL EtOAc
4. washwashed with 50 mL H2O
5. dry with materialdried (Na2SO4)
6. customevaporated
7. customThe residue was purified on silica gel