Acetone → 4-Chloro-N-isopropylaniline

HRID 1788590노트

반응식

HRID 1788590 반응식
[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.[CH3:9][C:10]([CH3:12])=O.[BH3-]C#N.[Na+].[O-]S([O-])(=O)=O.[Mg+2]>CCO.CC(O)=O>[Cl:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][CH:10]([CH3:12])[CH3:9])=[CH:4][CH:3]=1

참가 물질

7

반응물 4

HCID 180AcetoneHCID 78124-ChloroanilineHCID 24083Sulfuric acid magnesium salt (1:1)HCID 5003444Sodium cyanoborohydride

생성물 1

HCID 698644-Chloro-N-isopropylaniline수율 64.7%

시약·촉매·용매 2

HCID 176Acetic Acid용매HCID 702Ethanol용매

실험 절차

A mixture of 1 g (7.84 mmol) of 4-chloroaniline, 0.91 g (15.68 mmol) of acetone, 0.99 g (15.68 mmol) of NaCNBH3, 4 g of MgSO4 in 99 mL anhydrous EtOH and 1 mL AcOH was stirred at room temperature overnight, filtered and the solvent was removed. The residue was dissolved in 50 mL EtOAc, washed with 50 mL H2O, dried (Na2SO4) and evaporated. The residue was purified on silica gel using hexane/EtOAc as eluent to yield 0.86 g colorless oil. MS: 170.08 (M+H+).

후처리

  1. filtrationfiltered
  2. customthe solvent was removed
  3. dissolutionThe residue was dissolved in 50 mL EtOAc
  4. washwashed with 50 mL H2O
  5. dry with materialdried (Na2SO4)
  6. customevaporated
  7. customThe residue was purified on silica gel

출처 및 근거

ORD 기록
ord-d74673d792cc4db19d725f1bf05d5c6e
출처 데이터셋
uspto-grants-2009_03
특허 번호
US07511145B2

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