Hydrazine → HCID 5276085, compound

HRID 1788610Notes

Reaction equation

HRID 1788610 reaction equation
C([O:3][C:4]([C:6]1[CH:37]=[CH:36][C:9]2[N:10]([CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)[C:11]([C:13]3[CH:14]=[C:15]4[C:20](=[CH:21][CH:22]=3)[N:19]=[C:18]([C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH:17]=[C:16]4Cl)=[N:12][C:8]=2[CH:7]=1)=[O:5])C.[NH2:38][NH2:39].C1(N2C3C=CC(C(O)=O)=CC=3N=C2C2C=C3C(=CC=2)N=C(C2C=CC=CC=2)C=C3N(C)C)CCCCC1>>[CH:30]1([N:10]2[C:9]3[CH:36]=[CH:37][C:6]([C:4]([OH:3])=[O:5])=[CH:7][C:8]=3[N:12]=[C:11]2[C:13]2[CH:14]=[C:15]3[C:20](=[CH:21][CH:22]=2)[N:19]=[C:18]([C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:17]=[C:16]3[NH:38][NH2:39])[CH2:31][CH2:32][CH2:33][CH2:34][CH2:35]1

Participants

4

Reactant 3

HCID 9321HydrazineHCID 52761001-Cyclohexyl-2-[4-(dimethylamino)-2-phenyl-6-quinolyl]benzimidazole-5-carboxylic acidHCID 68924249HCID 68924249, compound

Product 1

HCID 5276085HCID 5276085, compound

Procedure

In this reaction 102 mg (0.2 mmol) of crude 2-(4-chloro-2-phenyl-quinolin-6-yl)-1-cyclohexyl-1H-benzoimidazole-5-carboxylic acid ethyl ester was reacted with hydrazine as the nucleophile as described for the preparation of Compound 481. Yield: 3.7 mg.

Sources & evidence

ORD record
ord-7dd4b2a4ef5644a1bfb4229c4d0aa572
Source dataset
uspto-grants-2009_03
Patent number
US07511145B2

Reaction notes

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