Hydrochloric Acid → 112111-01-0

HRID 1788653Notes

Reaction equation

HRID 1788653 reaction equation
CO[N:3]=[C:4]([C:8]1[N:9]=[N:10][S:11][CH:12]=1)[C:5]([OH:7])=[O:6].[ClH:13].[H][H]>CO.O>[ClH:13].[NH2:3][CH:4]([C:8]1[N:9]=[N:10][S:11][CH:12]=1)[C:5]([OH:7])=[O:6]

Participants

6

Reactant 3

HCID 313Hydrochloric AcidHCID 543473402-Methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetic acidHCID 178418361HCID 178418361, compound

Product 1

HCID 70444564112111-01-0

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-methoxyimino-2-(1,2,3-thiadiazol-4-yl)acetic acid (mixture of syn- and anti-isomers) (500 mg) [prepared by the method described in Belgian Pat. No. 859384 (1978)] in a mixture of methanol (10 cm3) and water (2.3 cm3) was treated with 1N hydrochloric acid (2.7 cm3) and hydrogenated under 50 psi of hydrogen with 5% rhodium-on-charcoal (500 mg) for one hour. A further portion of catalyst (500 mg) was added and hydrogenation continued for one hour. After filtration the filtrate was evaporated to dryness in vacuo and the residue triturated with ether to give the title compound as an off-white solid, (490 mg).

Workup

  1. filtrationAfter filtration the filtrate
  2. customwas evaporated to dryness in vacuo
  3. customthe residue triturated with ether

Sources & evidence

ORD record
ord-10d7e8c733bc4de0894890bb58362714
Source dataset
uspto-grants-1987_08
Patent number
US04684642

Reaction notes

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