反应详情

温度

150 °C

A mixture of ethyl (2-bromo-4,5-difluorobenzoyl)acetate (52.0 g), ethyl orthoformate (36.6 g) and acetic anhydride (41.6 g) is heated at 150° C. for 2 hours. After the reaction, the reaction mixture is concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (solvent, dichloromethane:n-hexane=2:1) to give ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate (49 g).

1. customAfter the reaction
2. concentrationthe reaction mixture is concentrated under reduced pressure
3. customThe resulting residue is purified by silica gel column chromatography (solvent, dichloromethane:n-hexane=2:1)