HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1788659Generated: October 26, 2026
Acetic Anhydride → Ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate
https://huagongshe.com/reaction/1788659
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl (2-bromo-4,5-difluorobenzoyl)acetate | HCID 13912599 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Product | Ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate | HCID 54231265 | 79.7% |
Reaction Steps
A mixture of ethyl (2-bromo-4,5-difluorobenzoyl)acetate (52.0 g), ethyl orthoformate (36.6 g) and acetic anhydride (41.6 g) is heated at 150° C. for 2 hours. After the reaction, the reaction mixture is concentrated under reduced pressure. The resulting residue is purified by silica gel column chromatography (solvent, dichloromethane:n-hexane=2:1) to give ethyl 2-(2-bromo-4,5-difluorobenzoyl)-3-ethoxyacrylate (49 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US04684648 |
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| Source dataset | uspto-grants-1987_08 |
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| ORD ID | ord-7af6035e622f47afb28a3eccd209e00d |
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| Source note | uspto-grants-1987_08 |
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